Vet Guide

Acute Oral Toxicities to Dogs

Table 1

Generic Name (ActiveTrade Namea) LD50 of Active Ingredient (mg/kg)b Usual % Active Ingredient in Bait Quantity of Bait to Give LD50 in 10 kg (22 lb) Dog Source of Data for LD50 Info (see Endnotes)
brodifacoum (d-Con®, Final®, Havoc®, Jaguar®, Ratak®, Talon®-G, Weatherblok®XT) 0.25-1.0 0.25-2.5 1.09-3.6 0.005c 50 g (1.8 oz) to 720 g (25.4 oz) 4, 5, 20 15 13
bromadiolone (BootHill®, Brigand™, Contrac®, Hawk®, JustOneBite®, Kaput®Doom, Maki®,Ratimor®, Ratoxin®, Resolv®, Revolver™) 11-15d 15-20 15-20 8.1 0.005 2,200 g (77.6 oz) to 4,000 g (141.1 oz) 14 2, 29 24 30
chlorophacinone (A-CFormula 90™, Borderline™, Rozol®) 50-100 50-100 50-100 0.005 10,000 g (352.7 oz) to 20,000 g (705.5 oz) 29 22 29
difenacoum (Di-Kill®, Multi-Kill®, Sorexa™) 50 0.005 10,000 g (352.7 oz) 19
difethialone (BlueMax™, d-Con®, FastDraw®, FirstStrike®, Generation®, Hombre™) 4 11.8 0.0025 1,600 g (56.4 oz) to 4,720 g (166.5 oz) 17 31
diphacinone (Ditrac®, Kaput®-D, Ramik®, TomCat®) 0.88 3.0-7.5 5-15 0.005 176 g (6.2 oz) to 3,000 g (105.8 oz) 21 18, 27, 29 6, 9, 23
warfarin (Kaput®, Rodex™) 20-50e 0.025 800 g (28.2 oz) to 2,000 g (70.5 oz) 7, 8, 20, 28

Table 1 Footnotes

a. See trade names for additional information regarding trademark ownership and affiliation.

b. Bold values LD50 range used in calculating ‘Quantity of Bait to Give LD50 in 10 kg Dog.’

c. This active ingredient is also available in .0025 (100 g to 1,440 g to reach LD50 in 10 kg dog.)

d. This is derived from a study which was not designed to obtain an LD50.

e. This LD50 range was originally established by the U.S. Fish and Wildlife Service, 1949.

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